SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth

Author:

Sun Ye1,Ju Meihua1,Lin Zhiqiang2,Fredrick Thomas W.1,Evans Lucy P.1,Tian Katherine T.1,Saba Nicholas J.1,Morss Peyton C.1,Pu William T.23,Chen Jing1,Stahl Andreas4,Joyal Jean-Sébastien5,Smith Lois E. H.1

Affiliation:

1. Department of Ophthalmology, Harvard Medical School, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.

2. Department of Cardiology, Harvard Medical School, Boston Children’s Hospital, Boston, MA 02115, USA.

3. Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

4. University Eye Hospital Freiburg, Killianstr. 5, Freiburg 79106, Germany.

5. Department of Pediatrics, Centre Hospitalier Universitaire (CHU) Sainte-Justine Research Center, Université de Montréal, Montréal, Québec H3T1C4, Canada.

Abstract

Enhancing SOCS3 activity in neurons and glial cells in the retina may prevent abnormal blood vessel formation in proliferative retinopathies.

Funder

Lowy Family Foundation

European Commission FP7

NIH/National Eye Institute

Boston Children';s Hospital (BCH) Career Development Award

BrightFocus Foundation

BCH Ophthalmology Foundation

Mass Lions Eye Research Fund Inc.

Alcon Research Institute

Deutsche Forschungsgemeinschaft

Deutsche Ophthalmologische Gesellschaft (DOG)

Burroughs Wellcome Fund Career Awards for Medical Scientists

Foundation Fighting Blindness

Canadian Child Health Clinician Scientist Program

Fonds de recherche du Quebec-Sante

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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