Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite-Reference-Cited by-同舟云学术

Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite

Published:2016-04-19 Issue:424 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Chebani Yacine¹,Marion Candice¹,Zizzari Philippe¹,Chettab Khadidja¹,Pastor Marie¹,Korostelev Marie¹,Geny David¹,Epelbaum Jacques¹²,Tolle Virginie¹,Morisset-Lopez Séverine³,Pantel Jacques¹⁴

Affiliation:

1. INSERM, Université Paris Descartes, Sorbonne Paris Cité, UMR-S 894, Centre de Psychiatrie & Neurosciences, 75014 Paris, France.

2. CNRS, Muséum national d’Histoire naturelle, UMR 7179, Mécanismes adaptatifs et évolution, 91800 Brunoy, France.

3. Centre de Biophysique Moléculaire, CNRS, UPR 4301, Université d’Orléans, 45071 Orléans, France.

4. Department of Molecular Physiology and Biophysics, Vanderbilt School of Medicine, Nashville, TN 37232, USA.

Abstract

Ghrelin promotes weight gain in the form of fat without increasing appetite.

Funder

INSERM

Fondation pour la Recherche Medicale

Danone Foundation

Universite Sorbonne Paris Cite

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference49 articles.

1. Ghrelin is a growth-hormone-releasing acylated peptide from stomach

2. Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens

3. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

4. Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens

5. Ghrelin induces adiposity in rodents

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