The transcription cofactor c-JUN mediates phenotype switching and BRAF inhibitor resistance in melanoma

Author:

Ramsdale Rachel12,Jorissen Robert N.34,Li Frederic Z.125,Al-Obaidi Sheren12,Ward Teresa12,Sheppard Karen E.126,Bukczynska Patricia E.78,Young Richard J.78,Boyle Samantha E.8910,Shackleton Mark58910,Bollag Gideon11,Long Georgina V.1213,Tulchinsky Eugene14,Rizos Helen1215,Pearson Richard B.25616,McArthur Grant A.1258,Dhillon Amardeep S.2510,Ferrao Petranel T.125810

Affiliation:

1. Molecular Oncology Laboratory, Peter MacCallum Cancer Centre, St. Andrew’s Place, East Melbourne, Victoria 3002, Australia.

2. Oncogenic Signalling and Growth Control Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

3. Systems Biology and Personalised Medicine Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria 3052, Australia.

4. Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria 3010, Australia.

5. Sir Peter MacCallum Department of Oncology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria 3010, Australia.

6. Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria 3010, Australia.

7. Molecular Therapeutics and Biomarkers Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

8. Cancer Therapeutics Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

9. Cancer Development and Treatment Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

10. Department of Pathology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria 3010, Australia.

11. Plexxikon Inc., 91 Bolivar Drive, Berkeley, CA 94710, USA.

12. Melanoma Institute Australia, Sydney, New South Wales 2060, Australia.

13. University of Sydney, Sydney, New South Wales 2006, Australia.

14. Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK.

15. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.

16. Cancer Signalling Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

Abstract

The transcriptional regulator c-JUN is a key mediator of the metastatic potential and drug resistance in melanoma.

Funder

Peter MacCallum Cancer Foundation

CASS Foundation

National Health and Medical Research Council of Australia

China Scholarships Council

Cancer Therapeutics CRC

Australian National Health and Medical Research Council

Pfizer Australia

Victorian Endowment for Science, Knowledge and Innovation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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