The acid-sensing ion channel ASIC1a mediates striatal synapse remodeling and procedural motor learning

Author:

Yu Zhe1ORCID,Wu Yan-Jiao1ORCID,Wang Yi-Zhi1,Liu Di-Shi1ORCID,Song Xing-Lei1,Jiang Qin1,Li Ying1,Zhang Siyu1,Xu Nan-Jie1ORCID,Zhu Michael Xi2ORCID,Li Wei-Guang1ORCID,Xu Tian-Le1ORCID

Affiliation:

1. Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

2. Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX 77030, USA.

Abstract

Motor learning and striatal neuronal function in mice are promoted by the acid-sensing channel ASIC1a.

Funder

National Institutes of Health

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

Shanghai Committee of Science and Technology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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