Conformational changes in the T cell receptor differentially determine T cell subset development in mice-Reference-Cited by-同舟云学术

Conformational changes in the T cell receptor differentially determine T cell subset development in mice

Published:2014-12-02 Issue:354 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Blanco Raquel¹,Borroto Aldo¹,Schamel Wolfgang²,Pereira Pablo³,Alarcon Balbino¹

Affiliation:

1. Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, 28049 Madrid, Spain.

2. BIOSS Centre for Biological Signalling Studies, Faculty of Biology, University of Freiburg and Max Planck Institute for Immunobiology and Epigenetics, 79108 Freiburg, Germany.

3. Institut Pasteur, Unité Limphopoïese, INSERM U668, 75015 Paris, France.

Abstract

Recruitment of the adaptor protein Nck to the T cell receptor complex contributes to the specification of T cells in the thymus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference60 articles.

1. αβ versus γδ fate choice: counting the T-cell lineages at the branch point

2. Towards a molecular understanding of the differential signals regulating αβ/γδ T lineage choice

3. Evidence That γδ versus αβ T Cell Fate Determination Is Initiated Independently of T Cell Receptor Signaling

4. The role of the T-cell receptor (TCR) in alphabeta/gammadelta lineage commitment: clues from intracellular TCR staining

5. Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage

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