Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis-Reference-Cited by-同舟云学术

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

Published:2014-09-16 Issue:343 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Daigo Kenji¹,Nakakido Makoto²,Ohashi Riuko³⁴,Fukuda Rie¹,Matsubara Koichi³,Minami Takashi⁵,Yamaguchi Naotaka⁶,Inoue Kenji⁷,Jiang Shuying³⁸⁹,Naito Makoto³,Tsumoto Kouhei²,Hamakubo Takao¹

Affiliation:

1. Department of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

2. Laboratory of Medical Proteomics, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

3. Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

4. Department of Pathology, Niigata University Medical and Dental Hospital, Niigata 951-8520, Japan.

5. Laboratory for Vascular Biology, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153-8904, Japan.

6. Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.

7. Department of Cardiology, Juntendo University Nerima Hospital, Tokyo 177-8521, Japan.

8. Niigata College of Medical Technology, Niigata 950-2076, Japan.

9. Perseus Proteomics Inc., Tokyo 153-0041, Japan.

Abstract

Bundling extracellular histone proteins together blocks their cytotoxic effects and protects against sepsis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference49 articles.

1. PENTRAXINS AT THE CROSSROADS BETWEEN INNATE IMMUNITY, INFLAMMATION, MATRIX DEPOSITION, AND FEMALE FERTILITY

2. An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

3. Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3

4. Interactions of the humoral pattern recognition molecule PTX3 with the complement system

5. The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules

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