Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca 2+ transfer for survival-Reference-Cited by-同舟云学术

Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca 2+ transfer for survival

Published:2020-07-14 Issue:640 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Cardenas Cesar¹²³⁴^ORCID,Lovy Alenka¹²⁵^ORCID,Silva-Pavez Eduardo¹²,Urra Felix²⁶^ORCID,Mizzoni Craig⁷,Ahumada-Castro Ulises¹²,Bustos Galdo¹²^ORCID,Jaňa Fabian²⁸^ORCID,Cruz Pablo¹²,Farias Paula¹²^ORCID,Mendoza Elizabeth¹²^ORCID,Huerta Hernan¹²^ORCID,Murgas Paola¹,Hunter Martin⁷^ORCID,Rios Melany¹²,Cerda Oscar⁹¹⁰¹¹^ORCID,Georgakoudi Irene⁷^ORCID,Zakarian Armen⁴,Molgó Jordi¹²^ORCID,Foskett J. Kevin¹³^ORCID

Affiliation:

1. Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago 8580745, Chile.

2. Geroscience Center for Brain Health and Metabolism, Santiago 8580745, Chile.

3. Buck Institute for Research on Aging, Novato, CA 94945, USA.

4. Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.

5. Department of Neuroscience, Center for Neuroscience Research, Tufts University School of Medicine, Boston, MA 02111, USA.

6. Program of Molecular and Clinical Pharmacology, Institute of Biomedical Science, Universidad de Chile, Santiago 8380453, Chile.

7. Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.

8. Universidad de Aysén, Coyhaique, 5952073, 8380453, Chile.

9. Program of Cellular and Molecular Biology, Institute of Biomedical Sciences (ICBM), Faculty of Medicine, Universidad de Chile, Santiago, Chile.

10. Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Santiago, Chile.

11. The Wound Repair, Treatment and Health (WoRTH), Santiago, Chile.

12. Université Paris-Saclay, CEA, Institut des Sciences du Vivant Frédéric Joliot, ERL CNRS n° 9004, Département Médicaments et Technologies pour la Santé, Service d’Ingénierie Moléculaire pour la Santé (SIMoS), bâtiment 152, Point courrier 24, F-91191 Gif sur Yvette, France.

13. Departments of Physiology and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Mitochondrial Ca 2+ influx promotes oxidative phosphorylation–independent pathways to enable cancer cell survival.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference62 articles.

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