Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry-Reference-Cited by-同舟云学术

Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry

Published:2020-09-08 Issue:648 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Nasa Isha¹²^ORCID,Cressey Lauren E.¹^ORCID,Kruse Thomas³,Hertz Emil P. T.³^ORCID,Gui Jiang⁴,Graves Lee M.⁵,Nilsson Jakob³,Kettenbach Arminja N.¹²^ORCID

Affiliation:

1. Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.

2. Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center at Dartmouth, Lebanon, NH 03766, USA.

3. Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.

4. Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, NH 03756, USA.

5. Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

Abstract

The kinase CDK1 directly and indirectly inhibits PP2A holoenzyme formation to promote mitosis.

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference64 articles.