Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21-Reference-Cited by-同舟云学术

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

Published:2011-11-15 Issue:199 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Merline Rosetta¹,Moreth Kristin¹,Beckmann Janet¹,Nastase Madalina V.¹,Zeng-Brouwers Jinyang¹,Tralhão José Guilherme²,Lemarchand Patricia³,Pfeilschifter Josef¹,Schaefer Roland M.⁴,Iozzo Renato V.⁵,Schaefer Liliana¹

Affiliation:

1. Pharmazentrum Frankfurt, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität Frankfurt am Main, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

2. Department of Surgery, Surgery 3, Coimbra University Hospital, 3000-075 Coimbra, Portugal.

3. Inserm, UMR915, Université de Nantes, CHU de Nantes, l’Institut du thorax, 44000 Nantes, France.

4. Department of Medicine D, University Hospital of Muenster, 48149 Muenster, Germany.

5. Department of Pathology, Anatomy and Cell Biology, and the Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107 USA.

Abstract

A component of the extracellular matrix promotes inflammatory responses in sepsis and in tumors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference65 articles.

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3. Downregulation of programmed cell death 4 by inflammatory conditions contributes to the generation of the tumor promoting microenvironment

4. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

5. The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation

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