GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma-Reference-Cited by-同舟云学术

GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma

Published:2020-08-18 Issue:645 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hayashi Masamichi¹²^ORCID,Guida Elisa¹,Inokawa Yoshikuni¹²,Goldberg Rachel¹,Reis Leonardo O.³^ORCID,Ooki Akira¹^ORCID,Pilli Manohar⁴,Sadhukhan Pritam¹^ORCID,Woo Juhyung⁵^ORCID,Choi Woonyoung⁶,Izumchenko Evgeny¹⁷,Gonzalez Leonel Maldonado¹⁸,Marchionni Luigi⁹^ORCID,Zhavoronkov Alex¹⁰^ORCID,Brait Mariana¹⁹^ORCID,Bivalacqua Trinity³,Baras Alexander⁵^ORCID,Netto George J.³⁵⁹,Koch Wayne¹,Singh Anju⁴^ORCID,Hoque Mohammad O.¹³⁹^ORCID

Affiliation:

1. Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

2. Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.

3. Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

4. Department of Environmental Health Sciences, School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

5. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

6. Johns Hopkins Greenberg Bladder Cancer Institute, Johns Hopkins University, Baltimore, MD 21287, USA.

7. Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA.

8. Department of Gynecology and Obstetrics–Gynecologic Specialties, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

9. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

10. Insilico Medicine Inc., Emerging Technology Centers, Johns Hopkins University at Eastern, B301, 1101 33rd Street, Baltimore, MD 21218, USA.

Abstract

GULP1 silencing increases NRF2-mediated antioxidant signaling that promotes urothelial carcinoma growth.

Funder

Allegheny Health Network-Johns Hopkins Cancer Research Fund

Flight Attendant Medical Research Institute Young Clinical Scientist Award

Career Development award from SPORE in Cervical Cancer Grants

Early Detection Research Network

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference55 articles.

1. Molecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy

2. The health economics of bladder cancer

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