Systematic Phosphorylation Analysis of Human Mitotic Protein Complexes

Author:

Hegemann Björn1,Hutchins James R. A.1,Hudecz Otto12,Novatchkova Maria12,Rameseder Jonathan3,Sykora Martina M.1,Liu Sihan3,Mazanek Michael12,Lénárt Péter14,Hériché Jean-Karim4,Poser Ina5,Kraut Norbert6,Hyman Anthony A.5,Yaffe Michael B.37,Mechtler Karl12,Peters Jan-Michael1

Affiliation:

1. Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria.

2. Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.

3. Departments of Biology and Biological Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

5. Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.

6. Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5-11, 1121 Vienna, Austria.

7. Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.

Abstract

Analysis of the phosphorylation of mitotic protein complexes suggests that specific members of the complexes relay regulatory signals to these molecular machines.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference77 articles.

1. The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists

2. Cellular strategies for the assembly of molecular machines

3. Microtubule Dynamics and Kinetochore Function in Mitosis

4. Here proteins are referred to by their official gene symbols: for human genes according to the Human Genome Organization (HUGO) nomenclature (http://www.genenames.org); for mouse genes according to the Mouse Genome Informatics (MGI) nomenclature (http://www.informatics.jax.org).

5. Mitotic kinases as regulators of cell division and its checkpoints

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