mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2-Reference-Cited by-同舟云学术

mTORC1 controls lysosomal Ca 2+ release through the two-pore channel TPC2

Published:2018-04-10 Issue:525 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Ogunbayo Oluseye A.¹^ORCID,Duan Jingxian¹,Xiong Jian²^ORCID,Wang Qiaochu²^ORCID,Feng Xinghua²^ORCID,Ma Jianjie³^ORCID,Zhu Michael X.²^ORCID,Evans A. Mark¹^ORCID

Affiliation:

1. Centres for Discovery Brain Sciences and Cardiovascular Sciences, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, EH8 9XD Scotland, UK.

2. Department of Integrative Biology and Pharmacology, McGovern Medical School, Program in Biochemistry and Cell Biology, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

3. Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA.

Abstract

The ion channel TPC2 is required for Ca 2+ mobilization from lysosomes in response to mTORC1 inhibition and to NAADP.

Funder

National Institute of General Medical Sciences

British Heart Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference40 articles.

1. Molecular Cloning of a Novel Form (Two-Repeat) Protein Related to Voltage-Gated Sodium and Calcium Channels

2. NAADP mobilizes calcium from acidic organelles through two-pore channels

3. Does nicotinic acid adenine dinucletoide phosphate elicit Ca2+ release via two-pore channel 2 in rat pulmonary arterial smooth muscle cells;Calcraft P.;Proc. Physiol. Soc.,2008

4. Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+ Currents in Isolated Lysosomes

5. TPC2 Is a Novel NAADP-sensitive Ca2+ Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

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