High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors-Reference-Cited by-同舟云学术

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors

Published:2020-06-16 Issue:636 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Bhola Patrick D.¹²^ORCID,Ahmed Eman¹,Guerriero Jennifer L.¹^ORCID,Sicinska Ewa¹,Su Emily¹^ORCID,Lavrova Elizaveta¹,Ni Jing¹,Chipashvili Otari¹^ORCID,Hagan Timothy¹^ORCID,Pioso Marissa S.¹,McQueeney Kelley¹,Ng Kimmie¹,Aguirre Andrew J.¹³,Cleary James M.¹,Cocozziello David³^ORCID,Sotayo Alaba¹^ORCID,Ryan Jeremy¹^ORCID,Zhao Jean J.¹³⁴,Letai Anthony¹²³^ORCID

Affiliation:

1. Dana-Farber Cancer Institute, Boston, MA 02215, USA.

2. Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

3. Broad Institute, Cambridge, MA 02115, USA.

4. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Effective treatments might be identified by rapidly profiling drug sensitivities in patient biopsies from solid tumors.

Funder

National Institutes of Health

U.S. Department of Defense

Publisher

American Association for the Advancement of Science (AAAS)