The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein-Reference-Cited by-同舟云学术

The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein

Published:2018-12-11 Issue:560 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kim TaeHee¹^ORCID,Mehta Suresh L.¹,Morris-Blanco Kahlilia C.¹,Chokkalla Anil K.¹²,Chelluboina Bharath¹,Lopez Mary¹²^ORCID,Sullivan Ruth³,Kim Hung Tae⁴^ORCID,Cook Thomas D.⁵^ORCID,Kim Joo Yong¹,Kim HwuiWon¹,Kim Chanul¹,Vemuganti Raghu¹²⁶^ORCID

Affiliation:

1. Department of Neurological Surgery, University of Wisconsin–Madison, Madison, WI 53792, USA.

2. Cellular and Molecular Pathology Graduate Program, University of Wisconsin–Madison, Madison, WI 53792, USA.

3. Department of Comparative Biosciences, University of Wisconsin–Madison, Madison, WI 53706, USA.

4. Department of Medicine, University of Wisconsin–Madison, Madison, WI 53705, USA.

5. Department of Biostatistics and Medical Informatics, University of Wisconsin–Madison, Madison, WI 53726, USA.

6. Williams S. Middleton Veterans Administration Hospital Madison, Madison, WI 53705, USA.

Abstract

Rapid intervention with an miR-7 mimic may protect the brain in patients who have had a stroke.

Funder

American Heart Association

NIH

US Department of Veterans Affairs Merit Review Grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference36 articles.

1. Molecular targets in cerebral ischemia for developing novel therapeutics

2. Protein Aggregation after Transient Cerebral Ischemia

3. Protein Aggregation and Proteasome Dysfunction After Brain Ischemia

4. Transient Focal Ischemia Induces Extensive Temporal Changes in Rat Cerebral MicroRNAome

5. MicroRNA Expression in the Blood and Brain of Rats Subjected to Transient Focal Ischemia by Middle Cerebral Artery Occlusion

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