Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist-Reference-Cited by-同舟云学术

Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist

Published:2012-02-14 Issue:211 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Bowen William S.¹²,Minns Laurie A.¹,Johnson David A.¹,Mitchell Thomas C.²,Hutton Melinda M.¹,Evans Jay T.¹

Affiliation:

1. GlaxoSmithKline Biologicals, 553 Old Corvallis Road, Hamilton, MT 59840, USA.

2. Institute for Cellular Therapeutics, University of Louisville School of Medicine, Donald Baxter Biomedical Research Building, 570 South Preston Street, Louisville, KY 40202, USA.

Abstract

A single change in a synthetic lipid A mimetic may reduce the toxicity of this vaccine adjuvant.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. Lipid A mimetics are potent adjuvants for an intranasal pneumonic plague vaccine

2. Toll-like receptor 4 agonists adsorbed to aluminium hydroxide adjuvant attenuate ovalbumin-specific allergic airway disease: role of MyD88 adaptor molecule and interleukin-12/interferon-γ axis

3. Agonists of Toll-Like Receptors 3, 4, 7, and 9 Are Candidates for Use as Adjuvants in an Outer Membrane Vaccine against Neisseria meningitidis Serogroup B

4. E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant

5. Synthetic TLR4-active Glycolipids as Vaccine Adjuvants and Stand-alone Immunotherapeutics

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