A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53-Reference-Cited by-同舟云学术

A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53

Published:2013-05-07 Issue:274 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kurokawa Manabu¹,Kim Jiyeon²,Geradts Joseph³,Matsuura Kenkyo²,Liu Liu⁴,Ran Xu⁴,Xia Wenle⁵,Ribar Thomas J.²,Henao Ricardo⁶,Dewhirst Mark W.⁷,Kim Wun-Jae⁸,Lucas Joseph E.⁶,Wang Shaomeng⁴,Spector Neil L.⁵,Kornbluth Sally²

Affiliation:

1. Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

2. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.

3. Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.

4. Comprehensive Cancer Center, Department of Internal Medicine, and Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

5. Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

6. Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA.

7. Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA.

8. Department of Urology, College of Medicine, Chungbuk National University, Cheongju, Chungbuk 361-711, Korea.

Abstract

Inhibition of the ubiquitin E3 ligase MDM2 in breast cancer cells could overcome lapatinib resistance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference45 articles.

1. p53 Mutations in Human Cancers

2. Mutational spectrum of p53 mutations in primary breast and ovarian tumors

3. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

4. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

5. Mdm2 promotes the rapid degradation of p53

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