RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms-Reference-Cited by-同舟云学术

RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms

Published:2016-07-26 Issue:438 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Yang Junning¹,Wu Chuanshen²,Stefanescu Ioana¹,Jakobsson Lars³,Chervoneva Inna⁴,Horowitz Arie¹

Affiliation:

1. Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

2. Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

3. Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm 17177, Sweden.

4. Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

RhoA signaling prevents the neural differentiation of embryonic stem cells by inhibiting both the production and secretion of the BMP antagonist Noggin.

Funder

NIH

William K. Bowes Jr. Foundation

Swedish Research Council

Swedish Cancer Society

Cardiovascular Program

Strategic Research Program in Neuroscience at Karolinska Institute

Jeanssons Stiftelser

Magnus Bergvalls Stiftelse

Publisher

American Association for the Advancement of Science (AAAS)

Subject