Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis-Reference-Cited by-同舟云学术

Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis

Published:2020-06-09 Issue:635 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Lovisa Sara¹^ORCID,Fletcher-Sananikone Eliot¹,Sugimoto Hikaru¹²,Hensel Janine¹^ORCID,Lahiri Sharmistha¹^ORCID,Hertig Alexandre²,Taduri Gangadhar²^ORCID,Lawson Erica¹,Dewar Rajan²^ORCID,Revuelta Ignacio²,Kato Noritoshi²,Wu Chang-Jiun³^ORCID,Bassett Roland L.⁴^ORCID,Putluri Nagireddy⁵^ORCID,Zeisberg Michael⁶,Zeisberg Elisabeth M.⁷,LeBleu Valerie S.¹²⁸^ORCID,Kalluri Raghu¹²⁵⁹^ORCID

Affiliation:

1. Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.

2. Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.

4. Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.

5. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

6. Department of Nephrology and Rheumatology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

7. Department of Cardiology and Pneumology, University Medical Center Göttingen, German Center for Cardiovascular Research (DZHK), Partner Site, Göttingen 37075, Germany.

8. Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

9. Department of Bioengineering, Rice University, Houston, TX 77030, USA.

Abstract

Kidney injury triggers endothelial-epithelial cellular crosstalk that culminates in fibrosis.

Funder

Cancer Prevention and Research Institute of Texas

University of Texas MD Anderson Cancer Center

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference67 articles.