Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING-Reference-Cited by-同舟云学术

Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING

Author:

Zamorano Cuervo Natalia¹^ORCID,Fortin Audray¹,Caron Elise¹^ORCID,Chartier Stéfany¹,Grandvaux Nathalie¹²^ORCID

Affiliation:

1. CRCHUM—Centre Hospitalier de l’Université de Montréal, 900 rue Saint Denis, Montréal, H2X 0A9 Québec, Canada.

2. Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, H3C 3J7 Québec, Canada.

Abstract

Ligand-dependent and -independent oxidation of cysteine residues in the adaptor protein STING regulates its conformation and activity.

Funder

Canadian Institutes of Health Research

Fonds de Recherche du Québec - Santé

Faculty of Medicine, Prince of Songkla University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference132 articles.

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