The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ-Reference-Cited by-同舟云学术

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ

Published:2017-07-25 Issue:489 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Chen Tzu-Chieh¹²^ORCID,Benjamin Daniel I.¹²,Kuo Taiyi²³,Lee Rebecca A.²³^ORCID,Li Mei-Lan²^ORCID,Mar Darryl J.²^ORCID,Costello Damian E.²³^ORCID,Nomura Daniel K.¹²³⁴,Wang Jen-Chywan¹²³^ORCID

Affiliation:

1. Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720–3104, USA.

2. Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720–3104, USA.

3. Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720–3104, USA.

4. Departments of Chemistry and Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720–3104, USA.

Abstract

Insulin resistance associated with glucocorticoid treatment may be alleviated by inhibiting the synthesis of ceramides or their effectors.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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