Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β-Reference-Cited by-同舟云学术

Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β

Published:2019-01-15 Issue:564 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Lodyga Monika¹^ORCID,Cambridge Elizabeth¹^ORCID,Karvonen Henna M.¹²^ORCID,Pakshir Pardis¹³,Wu Brian⁴⁵,Boo Stellar¹,Kiebalo Melanie¹^ORCID,Kaarteenaho Riitta²,Glogauer Michael⁶,Kapoor Mohit⁴⁵^ORCID,Ask Kjetil⁷^ORCID,Hinz Boris¹²⁶^ORCID

Affiliation:

1. Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

2. Respiratory Medicine, Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, POB 20, 90029, Oulu, Finland.

3. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

4. Department of Surgery and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5T 2S8, Canada.

5. Arthritis Program, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.

6. Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.

7. Department of Medicine, McMaster University, Firestone Institute for Respiratory Health, Hamilton, Ontario L8N 4A6, Canada.

Abstract

Adhesion with macrophages promotes the activation of fibroblasts into myofibroblasts and creates a self-sustaining profibrotic niche.

Funder

Canadian Institutes of Health Research

Canadian Foundation for Innovation

E-Rare Joint Transnational Program ‘Development of Innovative Therapeutic Approaches for Rare Diseases’

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference113 articles.

1. Myofibroblasts

2. Host Responses in Tissue Repair and Fibrosis

3. Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

4. Mechanisms of fibrosis: therapeutic translation for fibrotic disease

5. Idiopathic Pulmonary Fibrosis

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