The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development

Author:

Maruyama Takamitsu1,Mirando Anthony J.1,Deng Chu-Xia2,Hsu Wei13

Affiliation:

1. Department of Biomedical Genetics, Center for Oral Biology, University of Rochester Medical Center, Rochester, NY 14642, USA.

2. Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

3. James Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY 14642, USA.

Abstract

Imbalance of WNT and FGF signaling promotes premature closure of skull bones by inducing bone formation through chondrogenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference54 articles.

1. Genetics of craniofacial development and malformation

2. M. M. Cohen R. E. MacLean Craniosynostosis: Diagnosis Evaluation and Management (Oxford University Press New York 2000) p. 454.

3. Cranial sutures as intramembranous bone growth sites

4. B. K. Hall Bone (Telford Press Caldwell NJ 1990) pp. v.

5. Craniosynostosis: genes and mechanisms

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