Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis-Reference-Cited by-同舟云学术

Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis

Published:2014-03-11 Issue:316 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kallenberger Stefan M.¹²,Beaudouin Joël¹,Claus Juliane¹³,Fischer Carmen⁴,Sorger Peter K.⁵,Legewie Stefan⁶,Eils Roland¹

Affiliation:

1. Department for Bioinformatics and Functional Genomics, Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg 69120, Germany.

2. Kirchhoff Institute for Physics, Heidelberg University, Heidelberg 69120, Germany.

3. Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg 69120, Germany.

4. Apogenix GmbH, Heidelberg 69120, Germany.

5. Center for Cell Decision Processes, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

6. Institute of Molecular Biology, Mainz 55128, Germany.

Abstract

Dual modes of activation of caspase-8 enable precise control of apoptosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference61 articles.