Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability-Reference-Cited by-同舟云学术

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

Published:2016-05-17 Issue:428 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zvezdova Ekaterina¹,Mikolajczak Judith²³⁴⁵,Garreau Anne²³⁴⁵,Marcellin Marlène⁶,Rigal Lise²³⁴⁵,Lee Jan¹,Choi Seeyoung¹,Blaize Gaëtan²³⁴⁵,Argenty Jérémy²³⁴⁵,Familiades Julien²³⁴⁵,Li Liqi¹,Gonzalez de Peredo Anne⁶,Burlet-Schiltz Odile⁶,Love Paul E.¹,Lesourne Renaud²³⁴⁵

Affiliation:

1. Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

2. Centre de Physiopathologie de Toulouse Purpan, Toulouse F-31300, France.

3. Institut National de la Santé et de la Recherche Médicale, U1043, Toulouse F-31300, France.

4. Centre National de la Recherche Scientifique, U5282, Toulouse F-31300, France.

5. Université de Toulouse, Université Paul Sabatier, Toulouse F-31300, France.

6. Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse F-31077, France.

Abstract

The protein Themis1 enables thymocyte selection by promoting T cell receptor signaling.

Funder

INSERM

Sanofi

Intramural Research Program of the Eunice Kennedy Shriver, National Institute of Child Health and Human Development

Fondation pour la Recherche sur la Sclerose en Plaque (ARSEP)

Marie Curie International Reintegration

French Ministry of Higher Education and Research

Region Midi-Pyrenees

Fonds Europeens de Developpement Regional, FEDER

Toulouse metropole

French Ministry of Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference47 articles.

1. T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens

2. Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling

3. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

4. A Novel Gene Essential for the Development of Single Positive Thymocytes

5. Themis, a T cell–specific protein important for late thymocyte development

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1. Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development;Journal of Experimental Medicine;2024-07-09

2. THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA;Proceedings of the National Academy of Sciences;2024-05-07

3. THEMIS2 Impairs Antitumor Activity of NK Cells by Suppressing Activating NK Receptor Signaling;The Journal of Immunology;2024-04-15

4. Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation;Cellular and Molecular Life Sciences;2024-04-02

5. TCR Affinity and Signaling During Thymocyte Selection;Reference Module in Life Sciences;2024