Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice-Reference-Cited by-同舟云学术

Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice

Published:2021-02-09 Issue:669 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Mundy Christina¹^ORCID,Yao Lutian¹²^ORCID,Sinha Sayantani³^ORCID,Chung Juliet¹^ORCID,Rux Danielle¹^ORCID,Catheline Sarah E.¹^ORCID,Koyama Eiki¹^ORCID,Qin Ling⁴^ORCID,Pacifici Maurizio¹^ORCID

Affiliation:

1. Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

2. Department of Orthopaedics, The First Hospital of China Medical University, Liaoning 110001, China.

3. Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

4. Department of Orthopaedic Surgery, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Inhibition of endogenous activin A reduces heterotopic ossification and ectopic bone accumulation in mice.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference99 articles.

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5. A systematic review of the therapeutic interventions for heterotopic ossification after spinal cord injury

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