IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors-Reference-Cited by-同舟云学术

IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

Published:2012-12-18 Issue:255 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Evdokimova Valentina¹²,Tognon Cristina E.³,Benatar Tania¹,Yang Wenyi¹,Krutikov Konstantin¹,Pollak Michael⁴,Sorensen Poul H. B.³⁵,Seth Arun¹

Affiliation:

1. Biological Sciences Platform, Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M4N 3M5, Canada.

2. Institute of Protein Research, Pushchino, Moscow Region 142290, Russian Federation.

3. Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia V5Z 1L3, Canada.

4. Departments of Medicine and Oncology, McGill University and Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada.

5. Department of Pathology, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

Abstract

By inactivating the insulin-like growth factor receptor, IGFBP7 suppresses growth and promotes cell death.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference56 articles.

1. The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights

2. The role of insulin receptors and IGF-I receptors in cancer and other diseases

3. Defining the pathway to insulin-like growth factor system targeting in cancer

4. Insulin and insulin-like growth factor signalling in neoplasia

5. The insulin and insulin-like growth factor receptor family in neoplasia: an update

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