Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

Author:

O’Donnell Valerie B.1ORCID,Aldrovandi Maceler1ORCID,Murphy Robert C.2ORCID,Krönke Gerhard3

Affiliation:

1. Systems Immunity Research Institute, Cardiff University, Cardiff CF14 4XN, UK.

2. Department of Pharmacology, University of Colorado, 12801 East 17th Avenue, Aurora, CO 80045, USA.

3. Department of Internal Medicine 3–Rheumatology and Immunology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU) 91054, Erlangen, Germany.

Abstract

Enzymatically oxidized phospholipids have important functions in normal physiology and disease states.

Funder

National Institutes of Health

Wellcome Trust

British Heart Foundation

Royal Society

European Research Council

Deutsche Forschungsgemeinschaft

Else-Kroner Fresenius Stiftung

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference104 articles.

1. B. Halliwell J. M. C. Gutteridge Free Radicals in Biology and Medicine (Oxford Univ. Press 2015).

2. J. Berzelius I. Larbok I. V. Kemien H. A. Nordstrom Stockholm 1827 (1827).

3. Uber die Rolle des Eisens in der Atmung des Seeigeleis nebst Bemerkungen uber einige durch Eisen beschleunigte Oxydationen;Warburg O.;Hoppe-Seylers Z.,1914

4. OXIDATION OF PHOSPHOLIPID CATALYZED BY IRON COMPOUNDS WITH ASCORBIC ACID

5. 112. The course of autoxidation reactions in polyisoprenes and allied compounds. Part IX. The primary thermal oxidation product of ethyl linoleate

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