Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of T H 9 cells programmed by IL-7-Reference-Cited by-同舟云学术

Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of T H 9 cells programmed by IL-7

Published:2017-10-10 Issue:500 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Bi Enguang¹^ORCID,Ma Xingzhe¹,Lu Yong¹,Yang Maojie¹,Wang Qiang¹^ORCID,Xue Gang¹,Qian Jianfei¹,Wang Siqing²,Yi Qing¹^ORCID

Affiliation:

1. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

2. Department of Cancer Immunology, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130061, China.

Abstract

The cytokine IL-7 enhances the generation and antitumor activity of a T cell subset that may be used in cancer immunotherapy.

Funder

National Cancer Institute

Multiple Myeloma Research Foundation

Leukemia and Lymphoma Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference43 articles.

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4. IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

5. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

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