Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion-Reference-Cited by-同舟云学术

Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits T H 17 cell expansion

Published:2021-08-17 Issue:696 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Heise Denise¹^ORCID,Derrac Soria Alicia²,Hansen Selina¹^ORCID,Dambietz Christine¹^ORCID,Akbarzadeh Mohammad¹,Berg Anna F.¹^ORCID,Waetzig Georg H.³⁴^ORCID,Jones Simon A.²^ORCID,Dvorsky Radovan¹,Ahmadian Mohammad R.¹,Scheller Jürgen¹^ORCID,Moll Jens M.¹^ORCID

Affiliation:

1. Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine-University, Düsseldorf 40225, Germany.

2. Division of Infection and Immunity, School of Medicine, Systems Immunity University Research Institute, College of Biomedical and Life Sciences, Cardiff University, Cardiff CF14 4XN, UK.

3. Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Kiel 24105, Germany.

4. CONARIS Research Institute AG, Kiel 24118, Germany.

Abstract

Smaller, more selective molecular traps of IL-6 trans-signaling complexes may treat autoimmunity.

Funder

College of Dentistry, University of Kentucky

Society for Pediatric Radiology

American Dystonia Society

Department of Health

Museums Association

Deutsche Forschungsgemeinschaft

Ministry of Rural Affairs

Singapore-ETH Centre

Agence française pour la biodiversité

European Network on Noonan Syndrome and Related Disorders NSEuroNet

Versus Arthritis Programme

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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5. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells;Samoilova E. B.;J. Immunol.,1998

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