Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues-Reference-Cited by-同舟云学术

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

Published:2016-05-24 Issue:429 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Madak-Erdogan Zeynep¹,Kim Sung Hoon²,Gong Ping¹,Zhao Yiru C.¹,Zhang Hui³,Chambliss Ken L.³,Carlson Kathryn E.²,Mayne Christopher G.⁴,Shaul Philip W.³,Korach Kenneth S.⁵,Katzenellenbogen John A.²,Katzenellenbogen Benita S.¹

Affiliation:

1. Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

2. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

3. Center for Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390–9063, USA.

4. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

5. National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.

Abstract

Structurally redesigned estrogens improve metabolism and vascular repair without activating cell proliferation.

Funder

Breast Cancer Research Foundation

National Center for Complementary and Integrative Health (NCCIH)

Office of Dietary Supplements (ODS)

National Cancer Institute (NCI)

National Institute of Food and Agriculture

U.S. Department of Agriculture

NIH

Associates First Capital Corporation Distinguished Chair in Pediatrics at University of Texas (UT) Southwestern

Sun Yat-sen University, China

Division of Intramural Research, National Institute of Environmental Health Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference65 articles.

1. Breast Cancer, Estrogen Receptor and Ligands

2. Estrogen receptors and human disease

3. ERβ in breast cancer—Onlooker, passive player, or active protector?

4. The Consequences of Exhaustive Antiestrogen Therapy in Breast Cancer: Estrogen-Induced Tumor Cell Death

5. Recent insights into non-nuclear actions of estrogen receptor alpha

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