4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling-Reference-Cited by-同舟云学术

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

Author:

Philipson Benjamin I.¹²³^ORCID,O’Connor Roddy S.²^ORCID,May Michael J.⁴,June Carl H.²^ORCID,Albelda Steven M.³,Milone Michael C.²

Affiliation:

1. Medical Scientist Training Program, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, USA.

4. Department of Biomedical Sciences, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

Abstract

Noncanonical NF-κB signaling enhances the survival of CAR T cells expressing the 4-1BB costimulatory domain.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference104 articles.

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