Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

Author:

Singh Brijesh K.1ORCID,Sinha Rohit A.12,Tripathi Madhulika1,Mendoza Arturo3ORCID,Ohba Kenji14ORCID,Sy Jann A. C.1,Xie Sherwin Y.1ORCID,Zhou Jin1,Ho Jia Pei1ORCID,Chang Ching-yi5,Wu Yajun6ORCID,Giguère Vincent7ORCID,Bay Boon-Huat6ORCID,Vanacker Jean-Marc8,Ghosh Sujoy1ORCID,Gauthier Karine8,Hollenberg Anthony N.3,McDonnell Donald P.4ORCID,Yen Paul M.1

Affiliation:

1. Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke–National University of Singapore (NUS) Medical School, Singapore 169857, Singapore.

2. Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.

3. Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Sciences, 330 Brookline Avenue, Boston, MA 02215, USA.

4. Department of Internal Medicine, Enshu Hospital, Hamamatsu, Shizuoka 430-0929, Japan.

5. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, C238A Levine Science Research Center, Durham, NC 27710, USA.

6. Department of Anatomy, Yong Loo Lin School of Medicine, NUS, Singapore.

7. Goodman Cancer Research Centre, McGill University, 1160 Pine Avenue West, Montreal, Québec H3A 1A3, Canada.

8. Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon Cedex 07, France.

Abstract

The thyroid hormone receptor mediates its effects on key mitochondrial processes through ERRα.

Funder

National Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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