BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling-Reference-Cited by-同舟云学术

BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling

Published:2014-03-25 Issue:318 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sanchez-Laorden Berta¹²,Viros Amaya¹²,Girotti Maria Romina¹²,Pedersen Malin²,Saturno Grazia¹²,Zambon Alfonso³,Niculescu-Duvaz Dan³,Turajlic Samra²,Hayes Andrew⁴,Gore Martin⁴,Larkin James⁴,Lorigan Paul⁵,Cook Martin⁶,Springer Caroline³,Marais Richard¹²

Affiliation:

1. Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

2. Signal Transduction Team, The Institute of Cancer Research, London SW3 6JB, UK.

3. Gene and Oncogene Targeting Team, Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.

4. Melanoma Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.

5. Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.

6. Department of Histopathology, Royal Surrey County Hospital, Division of Clinical Pathology, University of Surrey, Guilford GU2 7XX, UK.

Abstract

When therapy leads to cancer metastasis, knowing where else to target in the pathway may be the key to successful treatment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

1. The MAPK signaling cascade

2. http://www.sanger.ac.uk/genetics/CGP/cosmic/.