Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4 + T cells-Reference-Cited by-同舟云学术

Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4 + T cells

Published:2019-09-17 Issue:599 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Dimeloe Sarah¹²,Gubser Patrick¹,Loeliger Jordan¹^ORCID,Frick Corina¹,Develioglu Leyla¹,Fischer Marco¹^ORCID,Marquardsen Florian³,Bantug Glenn R.¹,Thommen Daniela⁴^ORCID,Lecoultre Yannic¹,Zippelius Alfred⁴,Langenkamp Anja⁵^ORCID,Hess Christoph¹⁶^ORCID

Affiliation:

1. Immunobiology Laboratory, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

2. Institute of Immunology and Immunotherapy and Institute of Metabolism and Systems Research, University of Birmingham, Birmingham B15 2TT, UK.

3. Immunodeficiency Laboratory, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

4. Cancer Immunology Laboratory, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

5. Roche Innovation Center Basel, 4070 Basel, Switzerland.

6. Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK.

Abstract

The mitochondrial activity and antitumor function of human helper T cells are suppressed by a tumor-derived cytokine.

Funder

Hoffman-La Roche

Swiss National Science Foundation

University of Basel

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference38 articles.

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4. Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

5. Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

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