Bax Inhibitor-1 Is Likely a pH-Sensitive Calcium Leak Channel, Not a H + /Ca 2+ Exchanger-Reference-Cited by-同舟云学术

Bax Inhibitor-1 Is Likely a pH-Sensitive Calcium Leak Channel, Not a H + /Ca 2+ Exchanger

Published:2014-09-16 Issue:343 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Bultynck Geert¹,Kiviluoto Santeri¹,Methner Axel²

Affiliation:

1. KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Leuven, Belgium.

2. Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University Medical Center Mainz, Department of Neurology, Mainz, Germany.

Abstract

The structure of a bacterial Bax inhibitor-1 homolog suggests that Bax inhibitor-1 is an ER-localized Ca 2+ leak channel tightly controlled by the intracellular pH.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference13 articles.

1. Structural basis for a pH-sensitive calcium leak across membranes

2. The C Terminus of Bax Inhibitor-1 Forms a Ca2+-permeable Channel Pore

3. Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis

4. Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in Yeast

5. BI-1 Regulates an Apoptosis Pathway Linked to Endoplasmic Reticulum Stress

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