Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior-Reference-Cited by-同舟云学术

Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior

Published:2020-09-22 Issue:650 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Socodato Renato¹^ORCID,Henriques Joana F.¹^ORCID,Portugal Camila C.¹^ORCID,Almeida Tiago O.¹,Tedim-Moreira Joana¹^ORCID,Alves Renata L.¹^ORCID,Canedo Teresa¹²^ORCID,Silva Cátia¹,Magalhães Ana¹,Summavielle Teresa¹^ORCID,Relvas João B.¹²^ORCID

Affiliation:

1. Instituto de Investigação e Inovação em Saúde and Instituto de Biologia Molecular e Celular, Universidade do Porto, 4200-135 Porto, Portugal.

2. Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.

Abstract

Binge drinking may cause anxiety by triggering microglia to destroy excitatory synapses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference84 articles.

1. Synaptic Effects Induced by Alcohol

2. Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits

3. Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

4. Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

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