Transcriptional repressor REST drives lineage stage–specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma

Author:

Dobson Tara H. W.1ORCID,Tao Rong-Hua1ORCID,Swaminathan Jyothishmathi1,Maegawa Shinji1,Shaik Shavali1,Bravo-Alegria Javiera1ORCID,Sharma Ajay1,Kennis Bridget1,Yang Yanwen1,Callegari Keri1ORCID,Haltom Amanda R.1,Taylor Pete1ORCID,Kogiso Mari2,Qi Lin2,Khatua Soumen1,Goldman Stewart3ORCID,Lulla Rishi R.3,Fangusaro Jason3ORCID,MacDonald Tobey J.4,Li Xiao-Nan23ORCID,Hawkins Cynthia5,Rajaram Veena6ORCID,Gopalakrishnan Vidya178910ORCID

Affiliation:

1. Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

3. Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.

4. Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.

5. Department of Pathology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.

6. Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

7. Molecular and Cellular Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

8. Brain Tumor Center, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

9. Center for Cancer Epigenetics, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

10. The University of Texas MD Anderson Cancer Center–University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

Abstract

Functions of the transcription factor REST in SHH-type medulloblastoma may reveal new therapeutic targets.

Funder

National Institutes of Health

American Cancer Society

Rally Foundation

Cancer Prevention and Research Institute of Texas

The UT MD Anderson Cancer Center-CCE Scholar Program

Addis Faith Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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