Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease

Author:

Oliveira Mauricio M.12ORCID,Lourenco Mychael V.1ORCID,Longo Francesco2ORCID,Kasica Nicole P.3,Yang Wenzhong3,Ureta Gonzalo4,Ferreira Danielle D. P.5,Mendonça Paulo H. J.1,Bernales Sebastian4,Ma Tao3ORCID,De Felice Fernanda G.16,Klann Eric27ORCID,Ferreira Sergio T.18ORCID

Affiliation:

1. Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

2. Center for Neural Science, New York University, New York, NY 10003, USA.

3. Department of Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.

4. Fundación Ciencia & Vida, Santiago 7780272, Chile.

5. Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

6. Centre for Neuroscience Studies and Department of Psychiatry, Queen’s University, Kingston, ON K7L 3N6, Canada.

7. NYU Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.

8. Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

Abstract

Treatments that promote protein synthesis in the brain may preserve cognition in Alzheimer’s disease.

Funder

National Institutes of Health

Alzheimer’s Association

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Programa de Apoyo a Centros con Financiamiento Basal to Fundación Ciencia & Vida

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

International Society for Neurochemistry

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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