Solution of the Structure of the TNF-TNFR2 Complex

Author:

Mukai Yohei12,Nakamura Teruya3,Yoshikawa Mai12,Yoshioka Yasuo124,Tsunoda Shin-ichi145,Nakagawa Shinsaku2,Yamagata Yuriko3,Tsutsumi Yasuo146

Affiliation:

1. Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, Osaka 567-0085, Japan.

2. Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

3. Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan.

4. Center for Advanced Medical Engineering and Informatics, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

5. Department of Biomedical Innovation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

6. Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

Abstract

Structural differences in the binding of tumor necrosis factor to its two receptors may aid in the development of receptor-specific therapeutics.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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