DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis-Reference-Cited by-同舟云学术

DDR2 (discoidin domain receptor 2) suppresses osteoclastogenesis and is a potential therapeutic target in osteoporosis

Published:2015-03-24 Issue:369 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zhang Yan¹,Su Jin²,Wu Shufang¹,Teng Yue¹,Yin Zhanhai³,Guo Yan⁴,Li Jing¹,Li Kun⁵,Yao Libo²,Li Xu¹

Affiliation:

1. Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.

2. Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi’an, Shaanxi 710032, People’s Republic of China.

3. Department of Orthopaedics, the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi 710061, People’s Republic of China.

4. Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of China.

5. Clinical laboratory, ShanXi Mineral Hospital, Xi’an, Shaanxi 710014, People’s Republic of China.

Abstract

One receptor, DDR2, both promotes the differentiation of bone-depositing cells and prevents the differentiation of bone-resorbing cells.

Funder

National Natural Science Foundation of China

Specialized Research Fund for the Doctoral Program of Higher Education

Scientific Research Fund of the Shaanxi Provincial Department of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference42 articles.