Phosphorylation of FADD by the kinase CK1α promotes KRAS G12D -induced lung cancer-Reference-Cited by-同舟云学术

Phosphorylation of FADD by the kinase CK1α promotes KRAS G12D -induced lung cancer

Published:2015-01-27 Issue:361 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Bowman Brittany M.¹,Sebolt Katrina A.²,Hoff Benjamin A.³,Boes Jennifer L.³,Daniels Danette L.⁴,Heist Kevin A.³,Galbán Craig J.³,Patel Rajiv M.⁵,Zhang Jianke⁶,Beer David G.²,Ross Brian D.¹³,Rehemtulla Alnawaz²,Galbán Stefanie²

Affiliation:

1. Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

2. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.

3. Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.

4. Promega Corporation, Madison, WI 53711, USA.

5. Departments of Pathology and Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.

6. Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

Mutant KRAS promotes mitosis by stimulating phosphorylation of the adaptor protein FADD.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference48 articles.

1. Lung Cancer

2. The MAP kinase pathway is required for entry into mitosis and cell survival

3. FADD: a regulator of life and death

4. Molecular evidence for the nuclear localization of FADD

5. Phosphorylated FADD induces NF- B, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas

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