SERINC proteins potentiate antiviral type I IFN production and proinflammatory signaling pathways

Author:

Zeng Cong12ORCID,Waheed Abdul A.3,Li Tianliang4,Yu Jingyou12ORCID,Zheng Yi-Min12,Yount Jacob S.4,Wen Haitao4,Freed Eric O.3,Liu Shan-Lu1245ORCID

Affiliation:

1. Center for Retrovirus Research, Ohio State University, Columbus, OH 43210, USA.

2. Department of Veterinary Biosciences, Ohio State University, Columbus, OH 43210, USA.

3. Virus-Cell Interaction Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Frederick, MD 21702, USA.

4. Department of Microbial Infection and Immunity, Ohio State University, Columbus, OH 43210, USA.

5. Viruses and Emerging Pathogens Program, Infectious Diseases Institute, Ohio State University, Columbus, OH 43210, USA.

Abstract

The host restriction factor SERINC5 promotes intracellular innate signaling pathways to inhibit viral infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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