EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy-Reference-Cited by-同舟云学术

EGFR Signaling Through an Akt-SREBP-1–Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

Published:2009-12-15 Issue:101 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Guo Deliang¹,Prins Robert M.²,Dang Julie¹,Kuga Daisuke¹,Iwanami Akio¹,Soto Horacio²,Lin Kelly Y.¹,Huang Tiffany T.¹,Akhavan David¹,Hock M. Benjamin¹,Zhu Shaojun¹,Kofman Ava A.¹,Bensinger Steve J.¹,Yong William H.¹³,Vinters Harry V.¹⁴,Horvath Steve⁵,Watson Andrew D.⁶,Kuhn John G.⁷,Robins H. Ian⁸,Mehta Minesh P.⁸,Wen Patrick Y.⁹,DeAngelis Lisa M.¹⁰,Prados Michael D.¹¹,Mellinghoff Ingo K.¹⁰,Cloughesy Timothy F.³⁴,Mischel Paul S.¹³¹²

Affiliation:

1. Department of Pathology and Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

2. Department of Surgery, Division of Neurosurgery, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

3. Henry Singleton Brain Tumor Program and Jonsson Comprehensive Cancer Center, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

4. Department of Neurology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

5. Departments of Human Genetics and Biostatistics, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

6. Department of Medicine, Division of Cardiology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

7. University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

8. University of Wisconsin-Madison, Madison, WI 53711, USA.

9. Dana-Farber Cancer Institute, Boston, MA 02115, USA.

10. Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

11. University of California, San Francisco, San Francisco, CA 94143, USA.

12. Molecular and Medical Pharmacology, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.

Abstract

Inhibitors of fatty acid signaling promote apoptosis in glioblastoma cells with highly active EGFR signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference37 articles.

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