The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF 165 -induced angiogenesis-Reference-Cited by-同舟云学术

The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF 165 -induced angiogenesis

Published:2015-07-14 Issue:385 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Beckouche Nathan¹²³⁴⁵,Bignon Marine¹²³⁴,Lelarge Virginie¹²³⁴⁵,Mathivet Thomas¹²³,Pichol-Thievend Cathy¹²³⁴⁵,Berndt Sarah¹²³⁴,Hardouin Julie⁶,Garand Marion¹²³,Ardidie-Robouant Corinne¹²³⁴,Barret Alain¹²³⁴,Melino Gerry⁷,Lortat-Jacob Hugues⁸⁹¹⁰,Muller Laurent¹²³⁴,Monnot Catherine¹²³⁴,Germain Stephane¹²³⁴¹¹

Affiliation:

1. Collège de France, Center for Interdisciplinary Research in Biology, Paris F-75005, France.

2. CNRS, UMR 7241, Paris F-75005, France.

3. INSERM U1050, Paris F-75005, France.

4. Equipe Labellisée Ligue Contre le Cancer.

5. Universite Pierre et Marie Curie (ED 394), Paris F-75005, France.

6. Universite de Rouen Laboratoire Polymères Biopolymeres Surfaces, UMR CNRS 6270, Mont-Saint-Aignan F-76821, France.

7. MRC Toxicology Unit, University of Leicester, Leicester LE1 9HN, UK.

8. Université Grenoble Alpes, Institut de Biologie Structurale (IBS), Grenoble F-38000, France.

9. CNRS, IBS, Grenoble F-38000, France.

10. Commissariat à l’Energie Atomique et aux Energies Alternatives, Direction des Sciences du Vivant, IBS, Grenoble F-38000, France.

11. Department of Pathology, Saint-Louis Hospital, Assistance Publique–Hôpitaux de Paris, Paris F-75010, France.

Abstract

Transglutaminase-2 attenuates blood vessel formation by preventing heparan sulfate from potentiating signaling by a VEGF isoform.

Funder

Agence Nationale de la Recherche (ANR)

Ministere de l';Enseignement Superieur et de la Recherche

Fondation ARC pour la Recherche sur le Cancer

Groupe de Reflexion sur la Recherche Cardiovasculaire

Federation Francaise de Cardiologie

Societe Francaise de Cardiologie

Canceropole Ile-de-France

Labex MemoLife

French Infrastructure for Integrated Structural Biology

Grenoble Alliance for Integrated Structural Cell Biology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference41 articles.

1. Hypoxia-driven angiogenesis: Role of tip cells and extracellular matrix scaffolding;Germain S.;Curr. Opin. Hematol.,2010

2. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

3. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis

4. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms

5. Targeted Disruption of Heparan Sulfate Interaction with Hepatocyte and Vascular Endothelial Growth Factors Blocks Normal and Oncogenic Signaling

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