Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas-Reference-Cited by-同舟云学术

Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas

Published:2020-09 Issue:647 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Carabias Arturo¹^ORCID,Gómez-Hernández María¹^ORCID,de Cima Sergio¹^ORCID,Rodríguez-Blázquez Antonio¹^ORCID,Morán-Vaquero Alba¹^ORCID,González-Sáenz Patricia¹^ORCID,Guerrero Carmen¹²^ORCID,de Pereda José M.¹^ORCID

Affiliation:

1. Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Salamanca, 37007 Salamanca, Spain.

2. Departamento de Medicina, Facultad de Medicina, Universidad de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), 37007 Salamanca, Spain.

Abstract

Cancer-associated mutations in the GEF C3G may promote lymphoma progression by activating the GTPase Rap1.

Funder

Agencia Estatal de Investigacion & European Regional Development Fund

Consejeria de Educacion, Junta de Castilla y Leon & European Regional Development Fund

Consejeria de Educacion, Junta de Castilla y Leon

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference85 articles.

1. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G