Induction of metabolic quiescence defines the transitional to follicular B cell switch

Author:

Farmer Jocelyn R.12ORCID,Allard-Chamard Hugues13ORCID,Sun Na1,Ahmad Maimuna1ORCID,Bertocchi Alice1ORCID,Mahajan Vinay S.14ORCID,Aicher Toby1ORCID,Arnold Johan1,Benson Mark D.5ORCID,Morningstar Jordan5ORCID,Barmettler Sara2ORCID,Yuen Grace1ORCID,Murphy Samuel J. H.1ORCID,Walter Jolan E.678ORCID,Ghebremichael Musie1,Shalek Alex K.1910ORCID,Batista Facundo1ORCID,Gerszten Robert5,Pillai Shiv1ORCID

Affiliation:

1. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Department of Medicine, Harvard University, Cambridge, MA 02139, USA.

2. Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA.

3. Division of Rheumatology, Faculté de médecine et des sciences de la santé de l' Université de Sherbrooke et Centre de Recherche Clinique Étienne-Le Bel, Sherbrooke, Québec J1K 2R1, Canada.

4. Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

5. Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

6. Division of Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, St. Petersburg, FL 33602, USA.

7. Division of Allergy and Immunology, Department of Pediatrics, Johns Hopkins All Children’s Hospital, St. Petersburg, FL 33701, USA.

8. Division of Allergy and Immunology, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA 02114, USA.

9. Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

10. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02139, USA.

Abstract

Extracellular adenosine salvage and AMPK activation are enhanced in a stage-specific manner during human B cell development.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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