What Lies Beneath: Looking Beyond Tumor Genetics Shows the Complexity of Signaling Networks Underlying Drug Sensitivity-Reference-Cited by-同舟云学术

What Lies Beneath: Looking Beyond Tumor Genetics Shows the Complexity of Signaling Networks Underlying Drug Sensitivity

Published:2013-09-24 Issue:294 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Quaranta Vito¹,Tyson Darren R.¹

Affiliation:

1. Department of Cancer Biology, Vanderbilt University, School of Medicine, Nashville, TN 37232, USA.

Abstract

Two studies show the power of systems biology methods to improve cancer drug development and treatment strategy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference12 articles.

1. EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

2. Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation;Ono M.;Mol. Cancer Ther.,2004

3. BRAF targeted therapy changes the treatment paradigm in melanoma

4. Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

5. Computational Modeling of ERBB2 -Amplified Breast Cancer Identifies Combined ErbB2/3 Blockade as Superior to the Combination of MEK and AKT Inhibitors

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