Mechanism of Impaired NLRP3 Inflammasome Priming by Monophosphoryl Lipid A-Reference-Cited by-同舟云学术

Mechanism of Impaired NLRP3 Inflammasome Priming by Monophosphoryl Lipid A

Published:2011-05-03 Issue:171 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Embry Chelsea A.¹,Franchi Luigi²,Nuñez Gabriel²,Mitchell Thomas C.¹

Affiliation:

1. Department of Microbiology and Immunology and Institute for Cellular Therapeutics, University of Louisville School of Medicine, 570 South Preston Street, Louisville, KY 40202, USA.

2. Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Abstract

Biased signaling by an immune receptor ligand underlies its inability to induce inflammatory responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference56 articles.

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4. AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

5. A Potent Adjuvant Monophosphoryl Lipid A Triggers Various Immune Responses, but Not Secretion of IL-1β or Activation of Caspase-1

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