Temperature-activated ion channels in neural crest cells confer maternal fever–associated birth defects

Author:

Hutson Mary R.1ORCID,Keyte Anna L.123ORCID,Hernández-Morales Miriam2345ORCID,Gibbs Eric23ORCID,Kupchinsky Zachary A.6,Argyridis Ioannis23,Erwin Kyle N.1,Pegram Kelly1ORCID,Kneifel Margaret23ORCID,Rosenberg Paul B.7,Matak Pavle8,Xie Luke23ORCID,Grandl Jörg9,Davis Erica E.6ORCID,Katsanis Nicholas6,Liu Chunlei2345ORCID,Benner Eric J.1ORCID

Affiliation:

1. Division of Neonatology, Department of Pediatrics, Duke University Medical Center, Jean and George Brumley, Jr. Neonatal-Perinatal Institute, Durham, NC 27710, USA.

2. Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, NC 27710, USA.

3. Department of Radiology, Duke University School of Medicine, Durham, NC 27710, USA.

4. Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, USA.

5. Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.

6. Center for Human Disease Modeling, Duke University Medical Center, Durham, NC 27710, USA.

7. Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

8. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

9. Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Fever during the first trimester may induce birth defects by activating TRPV ion channels in neural crest cells.

Funder

National Institute of Mental Health

National Heart, Lung, and Blood Institute

National Institute of Biomedical Imaging and Bioengineering

American Heart Association

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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