SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors-Reference-Cited by-同舟云学术

SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors

Published:2018-01-30 Issue:515 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Roth Lee¹^ORCID,Srivastava Swati¹^ORCID,Lindzen Moshit¹,Sas-Chen Aldema¹,Sheffer Michal²^ORCID,Lauriola Mattia¹^ORCID,Enuka Yehoshua¹,Noronha Ashish¹^ORCID,Mancini Maicol¹,Lavi Sara¹,Tarcic Gabi¹^ORCID,Pines Gur¹^ORCID,Nevo Nava¹,Heyman Ori¹,Ziv Tamar³,Rueda Oscar M.⁴,Gnocchi Davide¹,Pikarsky Eli⁵,Admon Arie³^ORCID,Caldas Carlos⁴^ORCID,Yarden Yosef¹^ORCID

Affiliation:

1. Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel.

2. Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 76100, Israel.

3. The Smoler Protein Center, Department of Biology, Technion, Haifa 32000, Israel.

4. Cancer Research UK Cambridge Institute and the Cambridge Cancer Centre, Department of Oncology, University of Cambridge, Cambridge CB2 2XZ, UK.

5. Department of Immunology and Cancer Research and Department Pathology, Hebrew University-Hadassah Medical School, Jerusalem 91010, Israel.

Abstract

LAD1 coordinates EGF-stimulated changes in the cytoskeleton to support aggressive phenotypes in breast cancers.

Funder

National Cancer Institute

Israel Cancer Research Fund

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Seventh Framework Programme

European Research Council

the German-Israeli Project Cooperation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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